首页
登录
职称英语
Sleep deprivation is a quick and efficient way to treat depression. It works
Sleep deprivation is a quick and efficient way to treat depression. It works
游客
2025-03-29
25
管理
问题
Sleep deprivation is a quick and efficient way to treat depression. It works 60 to 70 percent of the time — far better than existing drugs — but the mood boost usually lasts only until the patient falls asleep. As an ongoing treatment, sleep deprivation is impractical, but researchers have been studying the phenomenon in an effort to uncover the cellular mechanisms behind depression and
remission
. Now a team at Tufts University has pinpointed glia as the key players.
The researchers previously found that astrocytes, a star-shaped type of glial cell, regulate the brain chemicals involved in sleepiness. During our waking hours, astrocytes continuously release the neurotransmitter adenosine, which builds up in the brain and causes " sleep pressure," the feeling of sleepiness and its related memory and attention impairments. The neurotransmitter causes this pressure by binding to adenosine receptors on the outside of neurons like a key fitting into a lock. As more adenosine builds up, more receptors are triggered, and the urge to sleep gets stronger.
In the new study, published online January 15 in the journal Translational Psychiatry, the scientists investigated whether this process is responsible for the antidepressant effects of sleep deprivation. Mice with depressive-like symptoms were administered three doses of a compound that triggers adenosine receptors, thus mimicking sleep deprivation. Although the mice continued to sleep normally, after 12 hours they showed a rapid improvement in mood and behavior, which lasted for 48 hours.
The results confirm that the adenosine buildup is responsible for the antidepressant effects of a lack of sleep. This finding points to a promising target for new drug development because it suggests that mimicking sleep deprivation chemically may offer the antidepressant benefits without the unwanted side effects of actually skipping sleep. Such an intervention could offer immediate relief from depression, in stark contrast with traditional antidepressants, which take six to eight weeks to kick in.
The study may also have implications beyond depression and sleep regulation, according to Dustin Hines, lead author and a postdoctoral fellow at Tufts. " For many years, neuroscientists focused almost exclusively on neurons, whereas the role of glia was neglected," Hines says. "We now know that glia play an important role in the control of brain function and have the potential to aid in the development of new treatments for many illnesses, including depression and sleep disorders." [br] What did Dustin Hines and his colleagues’ study suggest?
选项
A、Adenosine buildup accounts for why we feel sleepy.
B、Mice have similar depression symptoms as human beings.
C、Neurons and glias play key parts in controlling our brain function.
D、Causing sleepy feeling by using chemicals helps to ease depression.
答案
D
解析
本题是细节题,要求考生能够准确理解该研究的主要研究发现或结论。关键点在第四段中的“…adenosine buildup is responsible for the antidepressant effects of a lack of sleep”处。
转载请注明原文地址:https://tihaiku.com/zcyy/4017412.html
相关试题推荐
Sleepdeprivationisaquickandefficientwaytotreatdepression.Itworks
Sleepdeprivationisaquickandefficientwaytotreatdepression.Itworks
Sleepdeprivationisaquickandefficientwaytotreatdepression.Itworks
Sleepdeprivationisaquickandefficientwaytotreatdepression.Itworks
Sleepdeprivationisaquickandefficientwaytotreatdepression.Itworks
Sleepdeprivationisaquickandefficientwaytotreatdepression.Itworks
随机试题
HistoryofweatherforecastingEarlymethodsAlmanacsconnectedthewe
Neartheendofafive-daytourofhighlyautomated,high-techJapanesefacto
TheMissAmericacelebration【C1】______asabeautycontestin1921,butnowp
Hewasthespiritofregnantlaborashestoodthere,hishandsoutreachingtor
A.全部击中; B.至少有一发击中; C.必然击中; D.击中3发
编创打击乐声部伴奏。 要求: (1)自选打击乐器,为谱例《红河谷》编配第Ⅱ、
没有国家炮制规范标准的中药,应该由____制定标准A.国家药品监督管理局 B.
58、变电站带电水冲洗工作必须保证水质要求,母线冲洗时要投入可靠的()。
截至2019年12月31日,中国共产党党员总数为9191.6万名,同比增长1.4
(2015年11月)( )是指企业开展培训所获得的货币收益与培训总投入之间的
最新回复
(
0
)