______ so many difficulties, he didn’t give up his objection.A、regardless ofB、i

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问题 ______ so many difficulties, he didn’t give up his objection.

选项 A、regardless of
B、in case of
C、in spite of
D、despite of

答案 C

解析 regardless of意为“不管，不顾”；in case of意为“如果万一”；in spite of意为“尽管”；despite意为“尽管”，但它本身就是介词，后面不接of，所以C选项是正确答案。

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