首页
登录
职称英语
Scientists say they have high hopes for a drug that could one day provide a n
Scientists say they have high hopes for a drug that could one day provide a n
游客
2024-06-14
5
管理
问题
Scientists say they have high hopes for a drug that could one day provide a new form of treatment for HIV-A1DS. A compound, which interferes with an elusive protein used by the HIV virus to infect human cells, has worked extremely well in monkeys. If the drug proves effective in human trials, scientists say, it could bolster (加强) the effectiveness of two existing AIDS drugs, particularly in fighting drug-resistant strains of the virus.
Researchers at the pharmaceutical (制药的) company Merck are very excited about an experimental drug, which has worked as well in monkeys infected with a primate version of the virus as any of the existing anti-AIDS drugs.
It works by blocking one of three proteins, or enzymes, the HIV virus uses to gain entrance into and infect human immune system cells.
Inhibitor drugs have been developed to block two of the proteins, to slow progression of the disease after infection. They have become standard therapy as a "cocktail" for people infected with HIV.
Those erzymes are reverse transcriptase (转录酶) and protease (蛋白酶). The first converts the virus’ genetic material into that of its host cells. The second chops up the resulting larger proteins into smaller pieces, producing smaller viral particles that infect new cells.
The third prong of cellular attack is a protein called integrase(整合酶), which experts say has been harder to block. Once HIV fools host cells by changing its genetic information so it can enter them, integrase acts like a cut and paste operation in a word processor, deleting an immune cell’s genetic material and replacing it with its own.
An integrase inhibitor would give doctors a third line of attack against HIV infection, according to virologist Daria Hazuda of the division of Virus and Cell Biology at Merck.
"This would offer a third class of anti-retroviral medications that can be combined with reverse transcriptase inhibitors and protease inhibitors. And since it is a new mechanism of action, these compounds are active against multi-drug resistant variants. So variants that are resistant to all current therapies have been selected in HIV-patients," she said.
Current anti-AIDS drugs eventually become resistant to therapy, or stop working, because the virus changes its shape.
While researchers are encouraged by the success with the compound’s effectiveness in monkey trials, developing a drug that is equally effective in humans can be difficult.
Steven Young is executive director of the Department of Medicinal Chemistry at Merck. He says, if scientists find a compound that is equally effective in people, the company would ask U.S. regulators to speed approval of the drug.
"Yeah, I really think that’s what we’re hoping for," he said. "I mean, we need to get data that show it has robust anti-viral effects in people. And if we’re able to get that data, I think we would petition for Past track status."
Dr. Young says an integrase inhibitor has the potential to prevent drug resistance.
"To ensure our best chances of preventing resistance, we would give this as part of a cocktail therapy," he added. "And I think it’s really our plan that we would test this with reverse transcriptase inhibitors and protease inhibitors, as well."
选项
答案
fighting drug-resistant stratus of the virus
解析
根据题干中的关键词human trials和existing AIDS drugs 定位到第一段最后一句,可知科学家表示,该药物如果在人体试验中被证明是有效的,就会增强现存两种治疗艾滋病药物的效力,特别是在对抗病毒抗药性方面的效力,由此可得答案。
转载请注明原文地址:https://tihaiku.com/zcyy/3633542.html
相关试题推荐
Scientistssaytheyhavehighhopesforadrugthatcouldonedayprovidean
[originaltext]Scientistsclaimthatairpollutioncausesadeclineinthewo
WhatCANNOTbeinferredfromthefirstparagraph?[br]Nowscientistshavefound
Whatproportionoftheworld’selectricitysupplyisprovidedbyhydroelectricp
Whatproportionoftheworld’selectricitysupplyisprovidedbyhydroelectricp
Whatproportionoftheworld’selectricitysupplyisprovidedbyhydroelectricp
Whatproportionoftheworld’selectricitysupplyisprovidedbyhydroelectricp
Whatproportionoftheworld’selectricitysupplyisprovidedbyhydroelectricp
Before1965manyscientistspicturedthecirculationoftheocean’swatermas
Markoutthemistakesandputthecorrectionsintheblanksprovided.Ifyou
随机试题
Whatispopculture?Well,popis【11】forpopular.Thebeginningofpopcultu
根据有关法律规定,下列机构中一般不得作为贷款保证人的有()。A.公立医院
45岁女性患者因头痛头晕加重半天看急诊,自述近3年来明显发胖,近半年来口渴,乏力
生物医学模式向生物一心理一社会医学模式的转变,引起了医德的一系列变化,但应除外A
某测绘单位承担了某县地理国情普查项目,需要生产该县0.5m分辨率数字正射影像图(
阅读下面的材料,根据要求写作文。 教育学家陶行知说过:处处是想象创造之地,天天
人是自然性与社会性的统一体,个体的早期发展更多地体现了()。 A.自然属性
关于运动性言语中枢,下列说法正确的包括()。A、又称为布洛卡中枢B、主要负责“
基础心理学是研究()。 (A)正常成人心理现象的心理学基础学科 (B
女,19岁,上前牙松动3年,检查见上切牙松动Ⅱ°,扇形移位,口腔卫生较好,初步印
最新回复
(
0
)