首页
登录
职称英语
Scientists say they have high hopes for a drug that could one day provide a
Scientists say they have high hopes for a drug that could one day provide a
游客
2023-08-29
63
管理
问题
Scientists say they have high hopes for a drug that could one day provide a new form of treatment for HIV-AIDS. A compound, which interferes with an elusive protein used by the HIV virus to infect human cells, has worked extremely well in monkeys. If the drug proves effective in human trials, scientists say, it could bolster (加强) the effectiveness of two existing AIDS drugs, particularly in fighting drug-resistant strains of the virus.
Researchers at the pharmaceutical (制药的) company Merck are very excited about an experimental drug, which has worked as well in monkeys infected with a primate version of the virus as any of the existing anti-AIDS drugs.
It works by blocking one of three proteins, or enzymes, the HIV virus uses to gain entrance into and infect human immune system cells.
Inhibitor drugs have been developed to block two of the proteins, to slow progression of the disease after infection. They have become standard therapy as a "cocktail" for people infected with HIV.
Those enzymes are reverse transcriptase (转录酶) and protease (蛋白酶). The first converts the virus’ genetic material into that of its host cells. The second chops up the resulting larger proteins into smaller pieces, producing smaller viral particles that infect new cells.
The third prong of cellular attack is a protein called integrase (整合酶), which experts say has been harder to block. Once HIV fools host cells by changing its genetic information so it can enter them, integrase acts like a cut and paste operation in a word processor, deleting an immune cell’s genetic material and replacing it with its own.
An integrase inhibitor would give doctors a third line of attack against HIV infection, according to virologist Daria Hazuda of the division of Virus and Cell Biology at Merck.
"This would offer a third class of anti-retroviral medications that can be combined with reverse transcriptase inhibitors and protease inhibitors. And since it is a new mechanism of action, these compounds are active against multi-drug resistant variants. So variants that are resistant to all current therapies have been selected in HIV-patients," she said.
Current anti-AIDS drugs eventually become resistant to therapy, or stop working, because the virus changes its shape.
While researchers are encouraged by the success with the compound’s effectiveness in monkey trials, developing a drug that is equally effective in humans-can be difficult.
Steven Young is executive director of the Department of Medicinal Chemistry at Merck. He says, if scientists find a compound that is equally effective in people, the company would ask U. S. regulators to speed approval of the drug.
"Yeah, I really think that’s what we’re hoping for," he said. "I mean, we need to get data that show it has robust anti-viral effects in people. And if we’re able to get that data, I think we would petition for fast track status."
Dr. Young says an integrase inhibitor has the potential to prevent drug resistance.
"To ensure our best chance of preventing resistance, we would give this as part of a cocktail therapy," he added. "And I think it’s really our plan that we would test this with reverse transcriptase inhibitors and protease inhibitors, as well." [br] Why would anti-AIDS drugs stop working? ______.
选项
答案
Because the virus changes its shape
解析
根据题干中的“anti—AIDS drugs”和“stop working”可定位到第9段。答案明显为Becausethe virus changes its shape。
转载请注明原文地址:https://tihaiku.com/zcyy/2968106.html
相关试题推荐
[originaltext]Foryearsscientistshavebeenworriedabouttheeffectsof
[originaltext]Foryearsscientistshavebeenworriedabouttheeffectsof
Agrowingnumberofscientistsinsistthatanswerstotheworld’sproblemsw
Agrowingnumberofscientistsinsistthatanswerstotheworld’sproblemsw
Agrowingnumberofscientistsinsistthatanswerstotheworld’sproblemsw
Agrowingnumberofscientistsinsistthatanswerstotheworld’sproblemsw
Consumershadbetterchooseaproviderofacreditcardwith______.[br]Whatd
Consumershadbetterchooseaproviderofacreditcardwith______.[br]Ifyou
[originaltext]Americanscientistsaredevelopingmapsthatcanidentifyare
[originaltext]Americanscientistsaredevelopingmapsthatcanidentifyare
随机试题
下列胃、十二指肠溃疡出血的紧急处理,错误的是A.保守治疗24小时,出血控制后,宜
引起后天性支气管扩张的常见病因有A、肺炎支原体 B、衣原体 C、呼吸道合胞病
某女,29岁。孕2产1,间歇性下腹隐痛2年,常在劳累或性交后加重。月经4~5天/
依照《药品说明书和标签管理规定》规定,以下不符合有效期表述形式的是A有效期至20
47岁妇女,孕3产1,近2年来月经周期混乱,经量时多时少,最近闭经3个月后阴道淋
村集体经济组织财务公开的档案不包括( )。A.资源登记簿内容 B.财务审查、
(2017年真题)下列不属于个人经营贷款信用风险的内容的是()。A.借款人还款
A.单硬脂酸甘油酯 B.甘油 C.白凡士林 D.十二烷基硫酸钠 E.对羟
注册会计师在内部控制审计中识别业务流程可能发生错报的环节,下列做法中,错误的是(
关于施工过程水污染预防措施的说法,正确的有()。A.禁止将有毒有害废弃物作
最新回复
(
0
)