首页
登录
职称英语
Scientists say they have high hopes for a drug that could one day provide a n
Scientists say they have high hopes for a drug that could one day provide a n
游客
2023-09-10
57
管理
问题
Scientists say they have high hopes for a drug that could one day provide a new form of treatment for HIV-AIDS. A compound, which interferes with an elusive protein used by the HIV virus to infect human cells, has worked extremely well in monkeys. If the drug proves effective in human trials, scientists say, it could bolster (加强) the effectiveness of two existing AIDS drugs, particularly in fighting drug-resistant strains of the virus.
Researchers at the pharmaceutical (制药的) company Merck are very excited about an experimental drug, which has worked as well in monkeys infected with a primate version of the virus as any of the existing, anti-AIDS drugs.
It works by blocking one of three proteins, or enzymes, the HIV virus uses to gain entrance into and infect human immune system cells.
Inhibitor drugs have been developed to block two of the proteins, to slow progression of the disease after infection. They have become standard therapy as a "cocktail" for people infected with HIV
Those enzymes are reverse transcriptase (转录酶) and protease (蛋白酶). The first converts the virus’ genetic material into that of its host cells. The second chops up the resulting larger proteins into smaller pieces, producing smaller viral particles that infect new cells.
The third prong of cellular attack is a protein called integrase (整合酶), which experts say has been harder to block. Once HIV fools host cells by changing its genetic information so it can enter them. integrase acts like a cut and paste operation in a word processor, deleting on immune cell’s genetic material and replacing it with its own.
An integrase inhibitor would give doctors a third line of attack against HIV infection, according to virologist Daria Hazuda of the division of Virus and Cell Biology at Merck.
"This would offer a third class of anti-retroviral medications that can be combined with reverse transcriptase inhibitors and pretense inhibitors. And since it is a new mechanism of action, these compounds are active against multi-drug resistant variants. So variants that are resistant to all current therapies have been selected in HIV-patients," she said.
Current anti-AIDS drugs eventually become resistant to therapy, or stop working, because the virus changes its shape.
While researchers are encouraged by the success with the compound’s effectiveness in monkey trials, developing a drug that is equally effective in humans can be difficult.
Steven Young is executive director of the Department of Medicinal Chemistry at Merck. He says, if scientists find a compound that is equally effective in people, the company would ask U.S. regulators to speed approval of the drug.
"Yeah, I really think that’s what we’re hoping for." he said. "I mean. we need to get data that show it has robust anti-viral effects in people. And if we’re able to get that data. I think we would petition for fast track status."
Dr. Young says an integrase inhibitor has the potential to prevent drug resistance.
"To ensure our best chances of preventing resistance, we would give this as part of a cocktail therapy," he added. "And I think it’s really our plan that we would test this with reverse transcriptase inhibitors and pretense inhibitors, as well." [br] According to Steven Young, if scientists get the data that ______, they would petition for fast track status.
选项
答案
show the drug has robust anti-viral effects in people
解析
根据题干中的关键词Steven Young和fast track status定位到倒数第三、四段,可知Steven Young表示,他们需要得到表明药物在人体中有强力抗病毒效果的数据,而如果他们可以得到那样的数据,他们就可以申请快速审查,由此可得答案。
转载请注明原文地址:http://tihaiku.com/zcyy/3002320.html
相关试题推荐
[originaltext]ScientistsintheUnitedStateshavereportedsomegoodnews
Mostscientistsspendtheirtimeinlaboratories______(称称量量、用各和海洋生物做实验).inweig
AcrosstheUnitedStates,scientistsaremountingwhatmaybecomethemosti
AcrosstheUnitedStates,scientistsaremountingwhatmaybecomethemosti
[originaltext]Ifwinningiseverything,Britishscientistshavesomeadvice
[originaltext]Ifwinningiseverything,Britishscientistshavesomeadvice
[originaltext]Ifwinningiseverything,Britishscientistshavesomeadvice
[originaltext]Scientistssaythatmostdoctorsandpatientsalreadyknowwh
[originaltext]Scientistssaythatmostdoctorsandpatientsalreadyknowwh
ScientistssaythewarmingoftheEarth’satmospherehasbeguntoaffectpla
随机试题
Meetingscannotalwayssucceedinsolvingproblemsunderdiscussion.A、会议并非总能成功地
[originaltext]SentenceNo.1Australiahasmillionsofsheep.Theysaytherear
Sincethedawnofhumaningenuity(独创性),peoplehavedevisedevermorecunnin
采用成本法对在用低值易耗品评估时,成新率的确定应根据()确定,而不能完全按
某选修教材设置了“语言的艺术”选读专题,这一专题在《普通高中语文课程标准》(实验
流通蒸气灭菌法A.可使2ml安瓿3min内升温至140℃,呈现强杀菌效果 B.
在存货经济订货批量模型中,与经济订货量呈反方向变化的变量是( )。[2008年
在原始社会,当社会生产力还十分低下,人们的劳动所得除了维持人们自身的生存和繁衍外
3,5,8,13,20,()。 A.31B.33C.37D.44
在电子商务活动中,()是动机和目的。A.商流 B.物流 C.资金流 D.
最新回复
(
0
)