首页
登录
职称英语
An experimental treatment for Parkinson’s disease seemed to improve symptoms—
An experimental treatment for Parkinson’s disease seemed to improve symptoms—
游客
2025-01-13
21
管理
问题
An experimental treatment for Parkinson’s disease seemed to improve symptoms—dramatically so, for one 59-year-old man—without causing side effects in an early study of a dozen patients. The gene therapy treatment involved slipping billions of copies of a gene into the brain to calm overactive brain circuitry. More than half a million Americans have Parkinson’s. They endure symptoms that include tremors, rigidity in their limbs, slowness of movement and impaired balance and coordination. Eventually they can become severely disabled.
The small study focused on testing the safety of the procedure rather than its effectiveness, and experts cautioned it’s too soon to draw conclusions about how well it works. But they called the results promising and said the approach merits further studies. "We still have quite a bit more testing to do," said Dr. Michael Kaplitt of Weill Cornell Medical College in New York, an author of the study. Still, "the initial results are extremely encouraging".
Nathan Klein, a 59-year-old freelance television producer in Port Washington, N.Y., said the disease left him "pretty messed up". It weakened his voice, impaired his walking and made his hand tremble so badly he couldn’t hold a glass of wine without spilling it all. Klein was the first patient to be treated with Kaplitt’s gene therapy procedure in 2003, and he said his symptoms gradually subsided afterward. Nowadays, he said, apart from freezing now and then when he wants to walk, the symptoms are basically gone. "I’m elated," said Klein, who continues to take his regular pills for the disease. "It’s unbelievable."
Kaplitt, who has a financial interest in Neurologix Inc., which paid for the research, noted that the 12 patients in the study still have Parkinson’s symptoms. The amount of medication they were already taking for their symptoms didn’t change significantly in the year after the surgery. Current medicines can control symptoms, but can’t stop the disease from getting worse over time, and they can produce troublesome side effects like uncontrollable movement.
Some patients gain relief from a surgical treatment called deep brain stimulation, in which electrodes are placed in the brain and connected to a programmable stimulator. Kaplitt’s procedure was aimed at achieving the same goal as that surgery, calming overactive circuitry in the brain. It gets overactive because it loses the normal supply of a chemical called GABA. The gene therapy was designed to make the brain produce more GABA.
For the gene therapy surgery, a tube about the width of a hair was threaded through a hole about the size of a quarter at the top of the skull. The tube delivered a dose of a virus engineered to ferry copies of a gene into cells of a brain region called the subthalamic nucleus. The gene copies enable the cells to pump out more GABA. [br] Which of the following statements is the purpose of the third paragraph?
选项
A、To show that Parkinson’s disease can be cured.
B、To present typical symptoms.
C、To prove the promising results of the treatment.
D、To suggest how brilliant Kaplitt is.
答案
C
解析
转载请注明原文地址:https://tihaiku.com/zcyy/3911012.html
相关试题推荐
[originaltext]JeffseemedtobenomoresurprisedthanIdidwhenwelearnedth
[originaltext]JeffseemedtobenomoresurprisedthanIdidwhenwelearnedth
[originaltext]Inmanystressfulsituationsthebody’sresponsescanimprove
[originaltext]Inmanystressfulsituationsthebody’sresponsescanimprove
ForseveraldaysIsawlittleofMr.Rochester.Inthemorningheseemedmuc
ForseveraldaysIsawlittleofMr.Rochester.Inthemorningheseemedmuc
[originaltext]Doyouwanttoimprovethefirstimpressionyoumake?Doyou
[originaltext]Doyouwanttoimprovethefirstimpressionyoumake?Doyou
[originaltext]Doyouwanttoimprovethefirstimpressionyoumake?Doyou
[originaltext]Swimmingisoneofthebestformsofexercise.Itcanimprove
随机试题
DearMr.Hinson,Iwouldliketoconfirminwritingthearrangementsthatweagr
LeadersofChinacanexercisesoundjudgment,fortheyareall______acquaintedw
[originaltext]W:Howwillyouspendyoursummervacation?M:AtfirstIthought
在浮动汇率制下,各国的汇率是可以浮动的,但是在现实中,各国往往根据自身()等因素确立本国的汇率制度。A、经济发展水平B、金融市场规模C、开放程度
玻璃球喷头按灵敏度分为()。A.一般响应喷头 B.特殊响应喷头 C.
左房肥大的心电图改变为A.P波电压≥0.25mV B.P波低平 C.Ⅱ、Ⅲ导
某检测中心进行热轧带肋钢筋拉伸的委托检测项目,用户委托的热轧带肋钢筋试样技术参数
项目监理机构对设计成果审核后应提出( )。 A、评估报告 B、总结报告
阅读下面材料,回答问题。 “苦难是人生的一笔财富。”这是人们常说的一句激励
某项目建设一座单层库房,建筑层高为12米,占地面积50000平方米,建设一座占地
最新回复
(
0
)