首页
登录
职称英语
An experimental treatment for Parkinson’s disease seemed to improve symptoms—
An experimental treatment for Parkinson’s disease seemed to improve symptoms—
游客
2025-01-13
24
管理
问题
An experimental treatment for Parkinson’s disease seemed to improve symptoms—dramatically so, for one 59-year-old man—without causing side effects in an early study of a dozen patients. The gene therapy treatment involved slipping billions of copies of a gene into the brain to calm overactive brain circuitry. More than half a million Americans have Parkinson’s. They endure symptoms that include tremors, rigidity in their limbs, slowness of movement and impaired balance and coordination. Eventually they can become severely disabled.
The small study focused on testing the safety of the procedure rather than its effectiveness, and experts cautioned it’s too soon to draw conclusions about how well it works. But they called the results promising and said the approach merits further studies. "We still have quite a bit more testing to do," said Dr. Michael Kaplitt of Weill Cornell Medical College in New York, an author of the study. Still, "the initial results are extremely encouraging".
Nathan Klein, a 59-year-old freelance television producer in Port Washington, N.Y., said the disease left him "pretty messed up". It weakened his voice, impaired his walking and made his hand tremble so badly he couldn’t hold a glass of wine without spilling it all. Klein was the first patient to be treated with Kaplitt’s gene therapy procedure in 2003, and he said his symptoms gradually subsided afterward. Nowadays, he said, apart from freezing now and then when he wants to walk, the symptoms are basically gone. "I’m elated," said Klein, who continues to take his regular pills for the disease. "It’s unbelievable."
Kaplitt, who has a financial interest in Neurologix Inc., which paid for the research, noted that the 12 patients in the study still have Parkinson’s symptoms. The amount of medication they were already taking for their symptoms didn’t change significantly in the year after the surgery. Current medicines can control symptoms, but can’t stop the disease from getting worse over time, and they can produce troublesome side effects like uncontrollable movement.
Some patients gain relief from a surgical treatment called deep brain stimulation, in which electrodes are placed in the brain and connected to a programmable stimulator. Kaplitt’s procedure was aimed at achieving the same goal as that surgery, calming overactive circuitry in the brain. It gets overactive because it loses the normal supply of a chemical called GABA. The gene therapy was designed to make the brain produce more GABA.
For the gene therapy surgery, a tube about the width of a hair was threaded through a hole about the size of a quarter at the top of the skull. The tube delivered a dose of a virus engineered to ferry copies of a gene into cells of a brain region called the subthalamic nucleus. The gene copies enable the cells to pump out more GABA. [br] The passage is mainly about______.
选项
A、the gene therapy treatment
B、Parkinson’s disease
C、GABA
D、the research done by Dr. Michael Kaplitt
答案
A
解析
转载请注明原文地址:https://tihaiku.com/zcyy/3911009.html
相关试题推荐
ThelatePopehadcuredhimselfofParkinson’sdisease,thusmovingastepclose
ThelatePopehadcuredhimselfofParkinson’sdisease,thusmovingastepclose
ThelatePopehadcuredhimselfofParkinson’sdisease,thusmovingastepclose
ThelatePopehadcuredhimselfofParkinson’sdisease,thusmovingastepclose
[originaltext]Malariaisoneofthethreemostprevalentseriousdiseasesinth
[originaltext]Malariaisoneofthethreemostprevalentseriousdiseasesinth
[originaltext]Malariaisoneofthethreemostprevalentseriousdiseasesinth
[originaltext]Malariaisoneofthethreemostprevalentseriousdiseasesinth
WhichoneofthefollowingisNOTamajordiseaselistedinmedicalaidprograms
[originaltext]Ifyouwanttoimproveyourmemory,beconfident.Thatmayso
随机试题
Peterisgoingtoalake________hecanfishwithhisfriends.A、whichB、hereC、wh
奶奶吃“鲜”,现在想起来意味深长。在那样一个遥远的乡村,奶奶的生命与大自然紧密相连,天增岁月人增寿。她以感恩的心情,真情面对土地上的每一种果实的每一次成
ACompany’sBattletoShowItWasaVictimofAbusiveShort-
InthegrandschemeofthingsJeremyBenthamandJohnStuartMillarenormal
错
下列关于药物毒性反应的叙述,错误的是()。A.由药物剂量过大引起 B.对机体
下列选项中,属于资金筹集费的资金成本是()。A.股票股利 B.债券利息
下列工作内容,Ⅰ级无损检测人员不能()。A.签发检测报告 B.进行无损检测操作
软件设施主要完成通信网的控制、管理、运营和维护,实现通信网的()。A.科技化
行政法规可以规定的行政强制措施包括()。A.限制人身自由 B.冻结存款、汇款
最新回复
(
0
)