He was determined to sail around the world ______ his illness and old age.A、give

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问题 He was determined to sail around the world ______ his illness and old age.

选项 A、given
B、although
C、despite
D、in spite

答案 C

解析 despite是介词,意为“尽管”,等于in spite of,两者后面都接名词,作让步状语,答案为C。A、B后面通常接句子,填入题干,句意不通,故排除。
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