首页
登录
职称英语
Scientists say they have high hopes for a drug that could one day provide a n
Scientists say they have high hopes for a drug that could one day provide a n
游客
2024-06-01
27
管理
问题
Scientists say they have high hopes for a drug that could one day provide a new form of treatment for HIV-A1DS. A compound, which interferes with an elusive protein used by the HIV virus to infect human cells, has worked extremely well in monkeys. If the drug proves effective in human trials, scientists say, it could bolster (加强) the effectiveness of two existing AIDS drugs, particularly in fighting drug-resistant strains of the virus.
Researchers at the pharmaceutical (制药的) company Merck are very excited about an experimental drug, which has worked as well in monkeys infected with a primate version of the virus as any of the existing anti-AIDS drugs.
It works by blocking one of three proteins, or enzymes, the HIV virus uses to gain entrance into and infect human immune system cells.
Inhibitor drugs have been developed to block two of the proteins, to slow progression of the disease after infection. They have become standard therapy as a "cocktail" for people infected with HIV.
Those erzymes are reverse transcriptase (转录酶) and protease (蛋白酶). The first converts the virus’ genetic material into that of its host cells. The second chops up the resulting larger proteins into smaller pieces, producing smaller viral particles that infect new cells.
The third prong of cellular attack is a protein called integrase(整合酶), which experts say has been harder to block. Once HIV fools host cells by changing its genetic information so it can enter them, integrase acts like a cut and paste operation in a word processor, deleting an immune cell’s genetic material and replacing it with its own.
An integrase inhibitor would give doctors a third line of attack against HIV infection, according to virologist Daria Hazuda of the division of Virus and Cell Biology at Merck.
"This would offer a third class of anti-retroviral medications that can be combined with reverse transcriptase inhibitors and protease inhibitors. And since it is a new mechanism of action, these compounds are active against multi-drug resistant variants. So variants that are resistant to all current therapies have been selected in HIV-patients," she said.
Current anti-AIDS drugs eventually become resistant to therapy, or stop working, because the virus changes its shape.
While researchers are encouraged by the success with the compound’s effectiveness in monkey trials, developing a drug that is equally effective in humans can be difficult.
Steven Young is executive director of the Department of Medicinal Chemistry at Merck. He says, if scientists find a compound that is equally effective in people, the company would ask U.S. regulators to speed approval of the drug.
"Yeah, I really think that’s what we’re hoping for," he said. "I mean, we need to get data that show it has robust anti-viral effects in people. And if we’re able to get that data, I think we would petition for Past track status."
Dr. Young says an integrase inhibitor has the potential to prevent drug resistance.
"To ensure our best chances of preventing resistance, we would give this as part of a cocktail therapy," he added. "And I think it’s really our plan that we would test this with reverse transcriptase inhibitors and protease inhibitors, as well." [br] While integrase deletes an immune cell’s genetic material and replaces it with its own, it acts like ______in a word processor..
选项
答案
a cut and paste operation
解析
根据题干中的关键词word processor 定位到第六段第二句,可知HIV病毒一旦通过改变自身的遗传信息而诱导宿主细胞并进入其中,它就像文字处理软件中的剪切和粘贴程序一样,删除免疫细胞的遗传信息,并替换为自己的遗传信息。
转载请注明原文地址:https://tihaiku.com/zcyy/3614923.html
相关试题推荐
Noiseentersourearsaspowerfulwavesofmechanicalenergy.Scientistsmea
Noiseentersourearsaspowerfulwavesofmechanicalenergy.Scientistsmea
______(即使计算是正确的),scientistscanneverbesurethattheyhaveincludedallvar
Scientistsestimate______(还要过很多年这种药才能用在人身上).itwillbemanyyearsbeforethe
Themoretimescientistsspenddesigningcomputers,themoretheymarvelat
Themoretimescientistsspenddesigningcomputers,themoretheymarvelat
Themoretimescientistsspenddesigningcomputers,themoretheymarvelat
Thescientistshaveworkedout______.(一种可以大规模提高农业生产的方法)amethodbywhichthe
Scientistssaytheyhavehighhopesforadrugthatcouldonedayprovidean
Americaisacountrythatnowsitsatopthecherishedmyththatworkprovide
随机试题
[originaltext]Tomostofussharksarethemostdangerousfishintheseaa
A.serveB.sponsoredC.profitsD.principlesE.developingF.understa
手少阳三焦经的输穴是A.中渚 B.天井 C.支沟 D.液门 E.三间
处方开出当日有效,特殊情况由处方医师注明有效期限,最长不得超过A:7天B:2天
对于审计程序来说,不是必不可少的阶段的是:A.编制审计方案 B.发出审计通
党和国家在对资本主义工商业的社会主义改造中,采取了从低级到高级的国家资本主义的过
下列对松贝的性状特征描述正确的是A.鳞茎呈类圆锥形或近球形,外层鳞叶2瓣,大小悬
A.腭杆 B.腭板 C.舌托 D.舌面板 E.树脂基托缺失,可选择何种形
以下商品要申请出口质量许可证方可出口的有()。 A.玩具B.茶叶 C.输
在我国,主要承担银行和非银行金融机构,货币市场监管职责的机构有() A.
最新回复
(
0
)