Years ago, doctors often said that pain was a normal part of life. In pa

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问题       Years ago, doctors often said that pain was a normal part of life. In particular, when older patients【C1】__________of pain, they were told it was a natural part of aging and they would have to learn to live with it.
      Times have changed. Today, we take pain【C2】__________. Indeed, pain is now considered the fifth vital sign, as important as blood pressure, temperature, breathing rate and pulse in【C3】__________a person’s well-being. We know that chronic (慢性的) pain can disrupt (扰乱) a person’s life, causing problems that【C4】__________from missed work to depression.
      That’s why a growing number of hospitals now depend upon physicians who【C5】__________in pain medicine. Not only do we evaluate the cause of the pain, which can help us treat the pain better, but we also help provide comprehensive therapy for depression and other psychological and social【C6】__________related to chronic pain. Such comprehensive therapy often【C7】__________the work of social workers, psychiatrists (精神科医生) and psychologists, as well as specialists in pain medicine.
      This modern【C8】__________for pain management has led to a wealth of innovative treatments which are more effective and with fewer side effects than ever before. Decades ago, there were only a【C9】__________number of drugs available, and many of them caused【C10】__________side effects in older people, including dizziness and fatigue. This created a double-edged sword; the medications helped relieve the pain but caused other problems that could be worse than the pain itself.
A) complained
B) determining
C) gravely
D) involves
E) issues
F) limited
G) magnificent
H) prompting
I) range
J) relieved
K) seriously
L) respect
M) result
N) significant
O) specialize [br] 【C10】

选项

答案 N

解析根据句意可知，空格所在句和前一句在意义上是过去和现在的对比，前一句介绍现在药物的副作用时使用了fewer一词，所以空格处应该使用意义相对的词，结合选项可知，significant“影响明显的”符合句意。

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