首页
登录
职称英语
Scientists say they have high hopes for a drug that could one day provide a
Scientists say they have high hopes for a drug that could one day provide a
游客
2023-09-09
17
管理
问题
Scientists say they have high hopes for a drug that could one day provide a new form of treatment for H1V-AIDS. A compound, which interferes with an elusive protein used by the HIV virus to infect human cells, has worked extremely well in monkeys, If the. drug proves effective in human trials, scientists say, it could bolster (加强) the effectiveness of two existing AIDS drugs, particularly in fighting drug-resistant strains of the virus.
Researchers at the pharmaceutical(制药的) company Merck are very excited about an experimental drug, which has worked as well in monkeys infected with a primate version of the virus as any of the existing anti-AIDS drugs.
It works by blocking one of three proteins, or enzymes, the HIV virus uses to gain entrance into and infect human immune system cells.
Inhibitor drugs have been developed to block two of the proteins, to slow progression of the disease after infection. They have become standard therapy as a "cocktail" for people infected with HIV.
Those enzymes ere reverse transcriptase(转录酶) and protease (蛋白酶). The first converts the virus’ genetic material into that of its host cells. The second chops up the resulting larger proteins into smaller pieces, producing smaller viral particles that infect new cells.
The third prong of cellular attack is a protein called integrase(整合酶), which experts say has been harder to block. Once HIV fools host cells by changing its genetic information so it can enter them, integrase acts like a cut and paste operation in a word processor, deleting an immune cell’s genetic material and replacing it with its own.
An integrase inhibitor would give doctors a third line of attack against HIV infection, according to virologist Daria Hazuda of the division of Virus and Cell Biology at Merck.
"This would offer a third class of anti-retroviral medications that can be combined with reverse transcriptase inhibitors and protease inhibitors. And since it is a new mechanism of action, these compounds are active against multi-drug resistant variants. So variants that are resistant to all current therapies have been selected in HIV-patients," she said.
Current anti-AIDS drugs eventually become resistant to therapy, or stop working, because the virus changes its shape.
While researchers are encouraged by the success with the compound’s effectiveness in monkey trials, developing a drug that is equally effective in humans can be difficult.
Steven Young is executive director of the Department of Medicinal Chemistry at Merck. He says, if scientists find a compound that is equally effective in people, the company would ask U.S. regulators to speed approval of the drug.
"Yeah, I really think that’s what we’re hoping for," he said. "I mean, we need to get data that show it has robust anti-viral effects in people. And if we’re able to get that data, I think we would petition for fast track status."
Dr. Young says an integrase inhibitor has the potential to prevent drug resistance.
"To ensure our best chances of preventing resistance, we would give this as part of a cocktail therapy," he added. "And I think it’s really our plan that we would test this with reverse transcriptase inhibitors and protease inhibitors, as well." [br] While integrase deltas an immune cell’s genetic material and replaces it with its own, it acts like ______ in a word processor.
选项
答案
a cut and paste operation
解析
根据题干中的关键词word processor定位到第六段第二句,可知HIV病毒一旦通过改变自身的遗传信息而诱导宿主细胞并进入其中,它就像文字处理软件中的剪切和粘贴程序一样,删除免疫细胞的遗传信息,并替换为自己的遗传信息。
转载请注明原文地址:https://tihaiku.com/zcyy/2999646.html
相关试题推荐
[originaltext]Scientistssaythatmostdoctorsandpatientsalreadyknowwh
ScientistssaythewarmingoftheEarth’satmospherehasbeguntoaffectpla
ScientistssaythewarmingoftheEarth’satmospherehasbeguntoaffectpla
ScientistssaythewarmingoftheEarth’satmospherehasbeguntoaffectpla
ScientistssaythewarmingoftheEarth’satmospherehasbeguntoaffectpla
ScientistssaythewarmingoftheEarth’satmospherehasbeguntoaffectpla
ScientistssaythewarmingoftheEarth’satmospherehasbeguntoaffectpla
ScientistssaythewarmingoftheEarth’satmospherehasbeguntoaffectpla
ScientistssaythewarmingoftheEarth’satmospherehasbeguntoaffectpla
ScientistssaythewarmingoftheEarth’satmospherehasbeguntoaffectpla
随机试题
Hereallydidnothingpractical,forhe____________(不是看电视就是睡觉).eitherwatched
CaliforniaAhasnotonlythelargestBpopulationbutalsotheCmoreproductivee
Asmostschoolsaresetuptoday,learningiscompulsory.Itisanought,ev
Weseemtobelightonfuel.Theunderlinedpartmeans________.A、beeasytoget
试论坚持育人为本、立德树人的基本要求。
应用硝普钠时应注意下列哪些事项()A.出现厌食、恶心症状,应停药 B.密切
关于月经周期,下列哪项错误A.两次月经第1日的间隔时间称为月经周期 B.上次月
滴定液配制或使用错误的是A.盐酸滴定液(0.1mol/L)配制时,先用移液管精密
《招标投标法实施条例)规定,国有资金占控股或者主导地位的依法必须进行招标的项目,
依据《通用安装工程工程量计算规范》(GB50856-2013),对于在工业管道
最新回复
(
0
)