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  3. A personalized blood test that can identify tumor(肿瘤)DNA could be the first

A personalized blood test that can identify tumor(肿瘤)DNA could be the first

游客2023-08-27  55
问题     A personalized blood test that can identify tumor(肿瘤)DNA could be the first step towards a long-promised revolution in the way cancer is treated.
    In the short term, the test—reported by Victor Velculescu of Johns Hopkins Kimmel Cancer Center in Baltimore, Maryland, and his colleagues in Science Translational Medicine—could be used to spot cancer recurrence before tumor growth shows up on scans, meaning that treatment could be started earlier.
    The test detects genetic rearrangements that distinguish cancer cells from normal cells. Eventually it might also pave the way for more personalized cancer treatments tailored to the genetic signature of individuals’ tumors.
    Doctors already classify cancers by some of the genes that get switched on by the disease, and use this to guide treatment in some cases. For example, breast cancers are often divided into those that express oestrogen(雌激素)receptors on their surface and are therefore likely to respond to the drug tamoxifen(三苯氧胺), and those that don’t.
    Genes have also been identified that predict whether a variety of cancers are resistant to radiotherapy and certain drugs, and might therefore need a different sort of treatment. It is also possible to stratify(使分层)cancers into aggressive and non-aggressive subtypes(类型)according to their genetic make-up.
    But that’s just the beginning. In the future, pretty much all cancers are likely to be defined by the genetic pathways that drive their growth, rather than where in the body they manifest themselves. And because cancers mutate as they grow, it should be possible to track these changes and tailor patients’ therapies accordingly.
    Velculescu’s test is a step towards this. The real breakthrough will come when such blood tests become sophisticated enough to reveal how tumors are changing over time, rather than simply spotting that they have come back. That should truly revolutionize cancer treatment, enabling the most effective combinations of drugs to be tailored to individual patients—and without the need for painful tissue biopsies(生检采样). [br] How can scientists possibly distinguish cancers’ aggressive and non-aggressive subtypes?
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答案 According to their genetic make-up
解析 本题考查科学家划分癌症种类的根据。定位句指出，按照癌症基因的组成方式可以将其继续分为活力发展型和非活力发展型。题干中特殊疑问词how与原文according to对应，因此该词组后的名词性词组theirgenetic make—up符合题干语义要求，根据题干语法要求，本题答案为According to their genetic make-up．
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