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  3. Lonely people, it seems, are at greater risk than the gregarious(爱交际的)of dev

Lonely people, it seems, are at greater risk than the gregarious(爱交际的)of dev

游客2023-08-24  21
问题     Lonely people, it seems, are at greater risk than the gregarious(爱交际的)of developing illnesses associated with chronic inflammation(炎症), such as heart disease and certain cancers. A paper published last year in the Public Library of Science, Medicine shows the effect on mortality of loneliness is comparable with that of smoking and drinking after examining the results of 148 previous studies and controlled for factors such as age and pre-existing illness.
    Steven Cole of the University of California, Los Angeles, thinks he may know why this is so. He told the American Association for the Advancement of Science(AAAS)meeting in Washington, D. C. , about his work studying the expression of genes in lonely people. Dr. Cole harvested samples of white blood cells from both lonely and gregarious people. He then analyzed the activity of their genes, as measured by the production of a substance called messenger RNA. This molecule carries instructions from the genes telling a cell which proteins to make. The level of messenger RNA from most genes was the same in both types of people. There were several dozen genes, however, that were less active in the lonely, and several dozen others that were more active. Moreover, both the less active and the more active gene types came from a small number of functional groups.
    Broadly speaking, the genes less active in the lonely were those involved in staving off(避开)viral infections. Those that were more active were involved in protecting against bacteria. Dr. Cole suspects this could help explain not only why the lonely are iller, but how, in evolutionary terms, this odd state of affairs has come about. For inflammation is an antibacterial response.
    The crucial bit of the puzzle is that viruses have to be caught from another infected individual and they are usually species-specific. Bacteria, in contrast, often just lurk in the environment, and may thrive on many hosts. The gregarious are therefore at greater risk than the lonely of catching viruses, and Dr. Cole thus suggests that past evolution has created a mechanism(the details of which remain unclear)which causes white cells to respond appropriately. Conversely, the lonely are better off ramping up their protection against bacterial infection, which is a bigger relative risk to them.
    What Dr. Cole seems to have revealed, then, is a mechanism by which the environment(in this case the social environment)reaches inside a person’s body and tweaks its genome so that it responds appropriately. It is not that the lonely and the gregarious are genetically different from each other. Rather, their genes are regulated differently, according to how sociable an individual is. Dr. Cole thinks this regulation is part of a wider mechanism that tunes individuals to the circumstances they find themselves in. Where it goes wrong is when loneliness becomes chronic, and the inflammatory response becomes chronic at the same time. [br] What message does Dr. Cole seem to convey?
选项 A、Genes in the lonely people differ from those of the gregarious people.
B、Sociability can adjust a person’s genome and make it work properly.
C、The lonely people can become sociable if they regulate their genes.
D、Individuals have to find their own ways to adapt to the environment.
答案 B
解析 细节归纳题。由最后一段前三句可知，Cole博士似乎揭示出这样一种机制：社交环境可以到达人体内，调节人体内的基因组以让其作出恰当的反应。这并非说孤独的人和爱交际的人在基因上有所不同，而是根据交际程度的不同，这两种人以不同的方式调控各自的基因。综合上述信息可知，交际程度能调整人的基因组，使其得以良好运作，因此答案为B)。A)“孤独的人与爱交际的人在基因上有所不同”，与原文内容不符，故排除；C)“孤独的人如果调控基因可以变得好交际”，文中未提及，故排除；D)“个人要找到他们自己的方式来适应环境”，不符合Cole博士要表达的意思，故排除。
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