He was determined to sail around the world ______his illness and old age.A、given

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问题 He was determined to sail around the world ______his illness and old age.

选项 A、given
B、although
C、despite
D、in spite

答案 C

解析 despite是介词，意为“尽管”，等于in spite of，两者后面都接名词，作让步状语，答案为C。A、B后面通常接句子，填入题干，句意不通，故排除。

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