______is known to all, too much stress can cause disease.A、WhichB、ThatC、ItD、A

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问题 ______is known to all, too much stress can cause disease.

选项 A、Which
B、That
C、It
D、As

答案 D

解析考查固定搭配。句意：众所周知，太多的压力会引起疾病。as is known to all意为“众所周知”，是固定搭配。故选D。

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