首页
登录
职称英语
An experimental treatment for Parkinson’s disease seemed to improve symptoms—
An experimental treatment for Parkinson’s disease seemed to improve symptoms—
游客
2023-12-22
71
管理
问题
An experimental treatment for Parkinson’s disease seemed to improve symptoms—dramatically so, for one 59-year-old man—without causing side effects in an early study of a dozen patients. The gene therapy treatment involved slipping billions of copies of a gene into the brain to calm overactive brain circuitry. More than half a million Americans have Parkinson’s. They endure symptoms that include tremors, rigidity in their limbs, slowness of movement and impaired balance and coordination. Eventually they can become severely disabled.
The small study focused on testing the safety of the procedure rather than its effectiveness, and experts cautioned it’s too soon to draw conclusions about how well it works. But they called the results promising and said the approach merits further studies. "We still have quite a bit more testing to do," said Dr. Michael Kaplitt of Weill Cornell Medical College in New York, an author of the study. Still, "the initial results are extremely encouraging".
Nathan Klein, a 59-year-old freelance television producer in Port Washington, N.Y., said the disease left him "pretty messed up". It weakened his voice, impaired his walking and made his hand tremble so badly he couldn’t hold a glass of wine without spilling it all. Klein was the first patient to be treated with Kaplitt’s gene therapy procedure in 2003, and he said his symptoms gradually subsided afterward. Nowadays, he said, apart from freezing now and then when he wants to walk, the symptoms are basically gone. "I’m elated," said Klein, who continues to take his regular pills for the disease. "It’s unbelievable."
Kaplitt, who has a financial interest in Neurologix Inc., which paid for the research, noted that the 12 patients in the study still have Parkinson’s symptoms. The amount of medication they were already taking for their symptoms didn’t change significantly in the year after the surgery. Current medicines can control symptoms, but can’t stop the disease from getting worse over time, and they can produce troublesome side effects like uncontrollable movement.
Some patients gain relief from a surgical treatment called deep brain stimulation, in which electrodes are placed in the brain and connected to a programmable stimulator. Kaplitt’s procedure was aimed at achieving the same goal as that surgery, calming overactive circuitry in the brain. It gets overactive because it loses the normal supply of a chemical called GABA. The gene therapy was designed to make the brain produce more GABA.
For the gene therapy surgery, a tube about the width of a hair was threaded through a hole about the size of a quarter at the top of the skull. The tube delivered a dose of a virus engineered to ferry copies of a gene into cells of a brain region called the subthalamic nucleus. The gene copies enable the cells to pump out more GABA. [br] What does it mean by "impaired"(Para. 1)?
选项
A、Repaired.
B、Damaged.
C、Implicated.
D、Unpaired.
答案
B
解析
转载请注明原文地址:http://tihaiku.com/zcyy/3296451.html
相关试题推荐
[originaltext]Ifyouwanttoimproveyourmemory,beconfident.Thatmayso
Mostsorethroatsarecausedbyaninfectionwhichtreatmentwithantibiotic
Mostsorethroatsarecausedbyaninfectionwhichtreatmentwithantibiotic
Doctorsalonemustmakethefinaldecisionwhethertowithdrawtreatment,inc
Doctorsalonemustmakethefinaldecisionwhethertowithdrawtreatment,inc
Doctorsalonemustmakethefinaldecisionwhethertowithdrawtreatment,inc
[originaltext]Iftherewasasingleactthatwouldimproveyourhealth,cut
[originaltext]Iftherewasasingleactthatwouldimproveyourhealth,cut
[originaltext]JeffseemedtobenomoresurprisedthanIdidwhenwelearnedth
[originaltext]JeffseemedtobenomoresurprisedthanIdidwhenwelearnedth
随机试题
Ifsustainablecompetitiveadvantagedependsonworkforceskills,American
某工程双代号时标网络计划如下图所示(单位:天),关于时间参数的说法,正确的有(
求助者对于心理咨询师提出()的要求可能是移情。A.寻求现实的帮助 B.弥补过去
红外线激光水平仪不平的话,打开电源后,它会自动发出声音,水平之后就没有声音了
DMA工作方式下,在( )之间建立了直接的数据通路。A.CPU与外设 B.C
男性,33岁,从楼上不慎坠下,查体时发现腰以下各种感觉均消失,伴排尿障碍,其可能
对药品养护时库房温湿度的记录要求是A.每天上午一次B.每天上、下午定时各一次C.
个人经营贷款采用保证担保方式的贷款期限不得超过( )年。A.3 B.1 C
薪酬的公平性可以分为()层次。A.外部公平性 B.内部公平性 C.集体公平
如果分析投资大小对方案资金回收能力的影响,应选用().A、投资回收期分析指标
最新回复
(
0
)