________has been known for a hundred years, its commercial development has taken

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问题 ________has been known for a hundred years, its commercial development has taken place since the beginning of the century.

选项 A、Which
B、While
C、That
D、As

答案 D

解析它的商业发展始于本世纪初，已经被世人熟知一百年了。定语从句题。As作为关系代词，可以引导非限制性定语从句，指代后面的整个主句。故D项为正确答案。

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