______hard the question is, he can answer it appropriately.A、ThoughB、HoweverC、

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问题 ______hard the question is, he can answer it appropriately.

选项 A、Though
B、However
C、No matter
D、Despite

答案 B

解析无论问题有多难，他都能恰当地回答出来。however作副词，修饰形容词hard，意为“无论如何，不论到什么程度”；though为连词，引导从句；no matter与how连用时相当于however；despite作介词，后跟名词或动名词。

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